|
KMID : 0869220170210020067
|
|
Journal of Korean Geriatric Psychiatry
2017 Volume.21 No. 2 p.67 ~ p.74
|
|
|
Altered Cortical Thicknesses of Left Pars Opercularis and Left Lateral Occipital Gyrus Can Be Associated with Psychotic Symptoms in Patients with Alzheimer’s Disease
|
|
Lee Doo-Hyoung
Kim Gyung-Mee
Park Seon-Cheol
Kim Tae-Hyung
Choi Seung-Eun
Jeong Tae-Yeong
Lee Bong-Ju
Mun Chi-Woong
Lee Jung-Goo
Kim Young-Hoon
|
|
|
Abstract
|
|
|
Objective：The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/ subcortical volumes in patients with Alzheimer’s disease (AD).
Methods：Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner.
Results：AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups.
Conclusion：These results suggest that AD psychosis may reflect more severe deterioration of neuropathologic change in specific brain region.
|
|
|
KEYWORD
|
|
|
Alzheimer’s disease, Left lateral occipital gyrus, Left pars opercularis, Psychotic symptoms
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|